Mitosis Checkpoint: Ensuring Proper Attachment of Sister Chromatids

What is the checkpoint responsible for checking proper attachment of sister chromatids to the spindle microtubules in mitosis?

a) G2 checkpoint b) G1 checkpoint c) M checkpoint d) S checkpoint

Final answer:

The M checkpoint is responsible for checking proper attachment of sister chromatids to the spindle microtubules in mitosis.

Explanation:

The M checkpoint is responsible for checking if all sister chromatids are properly attached to the spindle microtubules before proceeding from metaphase to anaphase in mitosis.

During mitosis, the M checkpoint plays a critical role in ensuring the proper attachment of sister chromatids to the spindle microtubules. This checkpoint acts as a quality control mechanism to prevent errors in chromosome segregation, which could lead to genetic abnormalities.

As the cell progresses through the various stages of mitosis, the M checkpoint monitors the attachment of each sister chromatid to the microtubules of the spindle apparatus. If any errors or improper attachments are detected, the checkpoint will delay the progression of the cell cycle until the issues are resolved.

Proper attachment of sister chromatids to the spindle microtubules is essential for accurate chromosome segregation during cell division. If this attachment is not established correctly, it can result in unequal distribution of genetic material to the daughter cells, leading to potential genetic defects.

Overall, the M checkpoint serves as a crucial safeguard in ensuring the fidelity of chromosome segregation during mitosis. Understanding the roles of different checkpoints in the cell cycle can provide insights into the mechanisms that regulate cell division and maintain genomic stability.